2-(2-CHLORO-ACETYLAMINO)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:2-(2-CHLORO-ACETYLAMINO)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:76981-88-9
- Molecular formula:C14H18ClNO3S
- Molecular Weight:315.82
![ETHYL 2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXYLATE](/CAS/GIF/40106-13-6.gif)
40106-13-6
58 suppliers
$30.00/1g
79-04-9
365 suppliers
$12.00/5g
76981-88-9
17 suppliers
$189.00/500mg
Yield:76981-88-9 37%
Reaction Conditions:
with triethylamine in diethyl ether at 20; for 4 h;
Steps:
Preparation of 12
Compound 11 (2.0 g, 8.36 mmol) is dissolved in diethyl ether (60 mL) and treated with triethyl amine (1.3 mL, 9.2 mmol). To this mixture, chloroacetyl chloride (1.04 g, 9.2 mmol) dissolved in diethyl ether (5 mL) is added dropwise at room temperature. This mixture is stirred for 4 hours at room temperature. The mixture is partitioned between water (30 mL) and ether (30 mL). The organic layer is separated, dried [(MGS04)] and concentrated. The residue is subjected to chromatography by elution with [5%] ethyl acetate in heptane to give the desired product as a white solid (0.965 g, 37% yield). Physical characteristics: MS (ES-) for [M/Z] 314 (M-H) [+.]
References:
WO2003/101979,2003,A1 Location in patent:Page 22
105-56-6
439 suppliers
$10.00/5ml
76981-88-9
17 suppliers
$189.00/500mg
502-42-1
212 suppliers
$10.00/1g
76981-88-9
17 suppliers
$189.00/500mg