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ChemicalBook CAS DataBase List 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-
761440-16-8

4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h
4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling
4.2: 16 h / 20 °C

References:

WO2011/140338,2011,A1

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