ChemicalBook CAS DataBase List 7-Hydroxyquinolinone

7-Hydroxyquinolinone synthesis

10synthesis methods

Product Name:7-Hydroxyquinolinone
CAS Number:70500-72-0
Molecular formula:C9H7NO2
Molecular Weight:161.16

7-Hydroxyquinolinone can be used as pharmaceutical intermediates and is synthesized by 3,4-dihydro-7-hydroxy-2-quinolinone with palladium 10% on activated carbon in decalin at 180.

22246-18-0 Synthesis

22246-18-0
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$5.00/5g

70500-72-0
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$6.00/250mg

Yield:70500-72-0 90.9%

Reaction Conditions:

with palladium 10% on activated carbon in decalin at 180; for 8 h;

Steps:

1-7 Example 2:
100 g of 3,4-dihydro-7-hydroxy-2-quinolinone was added to a 3000 mL reaction flask, 2000 mL of decalin was added, and 10 g of 10% palladium carbon was finally added. The mixture was heated to 180 °C, stirred under reflux for 8 hours, cooled to room temperature, and 400 mL of a 2 mol/L sodium hydroxide solution was added thereto and the catalyst was filtered off. The separated aqueous layer was further added with 80 ml of a 10 mol/L hydrochloric acid solution and dried by filtration to obtain 89.7 g of an off-white powder of 7-hydroxy-2-quinolinone in a yield of 90.9%, purity (HPLC) 98.9%.

References:

Shanghai Pharmaceutical Industry Institute;China Pharmaceutical Industry Zongyuan;Zheng Zhiwei;Sui Qiang;Jiang Kaiyuan;Tang Chao;Gao Qi;Liu Shuai;Chen Jianli;Li Gen CN109776408, 2019, A Location in patent:Paragraph 0030-0043; 0047; 0048

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