ChemicalBook CAS DataBase List 7-bromo-6-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one

7-bromo-6-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one synthesis

5synthesis methods

Product Name:7-bromo-6-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS Number:5791-56-0
Molecular formula:C8H5BrClNO2
Molecular Weight:262.49

40372-61-0
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79-04-9 Synthesis

79-04-9
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7-bromo-6-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one

5791-56-0
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Yield:5791-56-0 82%

Reaction Conditions:

Stage #1: 2-amino-5-bromo-4-chlorophenol;chloroacetyl chloride in N,N-dimethyl-formamide at 0; for 1 h;
Stage #2: with potassium acetate in N,N-dimethyl-formamide at 20; for 16 h;

References:

Walker, Ann L.;Ancellin, Nicolas;Beaufils, Benjamin;Bergeal, Marylise;Binnie, Margaret;Bouillot, Anne;Clapham, David;Denis, Alexis;Haslam, Carl P.;Holmes, Duncan S.;Hutchinson, Jonathan P.;Liddle, John;McBride, Andrew;Mirguet, Olivier;Mowat, Christopher G.;Rowland, Paul;Tiberghien, Nathalie;Trottet, Lionel;Uings, Iain;Webster, Scott P.;Zheng, Xiaozhong;Mole, Damian J. [Journal of Medicinal Chemistry,2017,vol. 60,# 8,p. 3383 - 3404]