ChemicalBook CAS DataBase List 7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine

7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine synthesis

5synthesis methods

Product Name:7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
CAS Number:1032650-41-1
Molecular formula:C6H3BrClN3
Molecular Weight:232.47

93587-23-6 Synthesis

7-BROMO-1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE

93587-23-6
53 suppliers
$65.00/50mg

7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine

1032650-41-1
80 suppliers
$18.00/250mg

Yield: 93%

Reaction Conditions:

Stage #1:7-bromo-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one with trichlorophosphate at 115; for 3 h;
Stage #2: with potassium carbonate in water at 0 - 20;

Steps:

49
A mixture of 7-bromo-3,5-dihydropyrrolo[3,2-?]pyrimidin-4-one (100 mg, 0.5 mmol) and 6 mL of POCI3 under argon was warmed at 115°C. After 3 hours, the mixture was cooled to room temperature and poured over 300 mL of ice, stirred, made basic with potassium carbonate and extracted with EtOAc. The combined organic layers were dried, filtered, and concentrated in vacuo to provide 101 mg (93%) of the desired 7-bromo-4-chloro-5H-pyrrolo[3,2- djpyrimidine as beige solid which was used without further purification.

References:

Location in patent:Page/Page column 153

84905-80-6 Synthesis