天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE
690632-05-4

TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE synthesis

1synthesis methods
6329-74-4 Synthesis
5-BROMOSALICYLAMIDE

6329-74-4
90 suppliers
$6.00/1g

79099-07-3 Synthesis
N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3
543 suppliers
$5.00/5g

-

Yield:690632-05-4 63%

Reaction Conditions:

with pyrrolidine at 72; for 2 h;Microwave irradiation;

Steps:



Three batches of 5-bromo salicylamide (4, 5.00g each, 23.1mmol), N-Boc-piperidin-4-one (3.45g, 17.3mmol) and pyrrolidine (1.64g, 23.1mmol) were heated in different flasks at 72°C under MW irradiation for 1h. Further N-Boc-piperidin-4-one (3.45g, 17.3mmol) was added and the mixtures were heated for 1h at 72°C. The resulting precipitates were collected by filtration and washed with MeOH to give the spirocycle 5 (17.2g, 63%) as a white solid. 1H NMR (300MHz, DMSO-d6): δ=8.86 (s, 1H), 7.82 (d, J=2.35Hz, 1H), 7.69 (dd, J=8.66, 2.49Hz, 1H), 7.06 (d, J=8.80Hz, 1H), 3.64-3.88 (m, 2H), 3.02-3.21 (m, 2H), 1.91-2.10 (m, 2H), 1.63-1.78 (m, 2H), 1.40ppm (s, 9H).

References:

Thaler, Florian;Varasi, Mario;Abate, Agnese;Carenzi, Giacomo;Colombo, Andrea;Bigogno, Chiara;Boggio, Roberto;Zuffo, Roberto Dal;Rapetti, Daniela;Resconi, Anna;Regalia, Nickolas;Vultaggio, Stefania;Dondio, Giulio;Gagliardi, Stefania;Minucci, Saverio;Mercurio, Ciro [European Journal of Medicinal Chemistry,2013,vol. 64,p. 273 - 284]

TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE Related Search: