6-BROMO-2-PHENYL-1H-QUINAZOLIN-4-ONE synthesis

13synthesis methods

Product Name:6-BROMO-2-PHENYL-1H-QUINAZOLIN-4-ONE
CAS Number:27398-50-1
Molecular formula:C14H9BrN2O
Molecular Weight:301.14

21740-00-1 Synthesis

21740-00-1
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$8.00/5g

1670-14-0 Synthesis

1670-14-0
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$6.00/10g

27398-50-1
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Yield:27398-50-1 92%

Reaction Conditions:

with 8-quinolinol;sodium hydroxide;copper dichloride in water at 20; for 0.333333 h;Sealed tube;Microwave irradiation;chemoselective reaction;

Steps:

Experimental

General procedure: In a 10 mL glass tube 2-iodobenzoic acid (1.0 mmol), acetamidine hydrochloride (1.2 mmol), CuCl₂ (0.1 mmol), L2 (0.1 mmol), and NaOH (4.0 equiv.) and 3.0 mL water were placed. The vessel was then sealed with a septum and placed into the microwave cavity. Initial microwave irradiation of 120 W by using a CEM Discover microwave synthesizer was used at the room temperature for 20 min. The reaction mixture was stirred continuously during the reaction. After completion of the reaction, the solvent was removed in vacuo. The residue was purified by silica gel column chromatography to afford the corresponding product. All the products were confirmed by NMR and MS spectroscopic analysis.

References:

Ke, Fang;Liu, Caiqin;Zhang, Peng;Xu, Jianhua;Chen, Xiaole [Synthetic Communications,2018,vol. 48,# 24,p. 3089 - 3098] Location in patent:supporting information