ChemicalBook CAS DataBase List 5-(MORPHOLIN-4-YLSULFONYL)-1H-INDOLE-2,3-DIONE

5-(MORPHOLIN-4-YLSULFONYL)-1H-INDOLE-2,3-DIONE synthesis

5synthesis methods

Product Name:5-(MORPHOLIN-4-YLSULFONYL)-1H-INDOLE-2,3-DIONE
CAS Number:220510-03-2
Molecular formula:C12H12N2O5S
Molecular Weight:296.3

3,3-dichloro-5-morpholin-4-ylsulfonyl-1H-indol-2-one

220428-21-7
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5-(MORPHOLIN-4-YLSULFONYL)-1H-INDOLE-2,3-DIONE

220510-03-2
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$175.00/250mg

Yield:-

Reaction Conditions:

with acetic acid in water at 90;

Steps:

4.1.4 General procedure for the synthesis of compounds 7a-m

Under nitrogen atmosphere, mixture of 4 and 5 (2.0mmol) was dissolved in 6ml of dried THF at 0°C. Then, a solution of the secondary amine (2.2mmol) and diisopropylethylamine (3.0mmol) in 1ml of THF was slowly added. After stirring the reaction mixture at room temperature overninght, solvents were removed and a brown oil was obtained. The crude product was added to 15ml of 1:1 (v/v) acetic acid-water solution. The mixture was heated at 90°C overnight. About 11g of NaHCO₃ was carefully added to the mixture after cooling down. The product was extracted by ethylacetate, washed with water, and dried over MgSO₄. Target compound 7 was purified by column chromatography using CH₂Cl₂ and CH₃OH.

References:

Liu, Wei;Zhu, He-Min;Niu, Guo-Jun;Shi, En-Zhi;Chen, Jie;Sun, Bo;Chen, Wei-Qiang;Zhou, Hong-Gang;Yang, Cheng [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 1,p. 292 - 302]

110-91-8 Synthesis