ChemicalBook CAS DataBase List 5-Chloroquinoxaline

5-Chloroquinoxaline synthesis

8synthesis methods

Product Name:5-Chloroquinoxaline
CAS Number:62163-09-1
Molecular formula:C8H5ClN2
Molecular Weight:164.59

131543-46-9 Synthesis

131543-46-9
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21745-41-5 Synthesis

21745-41-5
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62163-09-1
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Yield:62163-09-1 97%

Reaction Conditions:

with 10 wtpercent sulfated polyborate in neat (no solvent) at 100; for 0.05 h;Green chemistry;

Steps:

2.3 General procedure for the synthesis of quinoxaline derivatives

General procedure: To a mixture of substituted o-phenylenediamines derivative(2.0 mmol) and 1,2-diketone / α-hydroxy ketone (2.0 mmol),was added sulfated polyborate (10 wt%). The reaction mixture was stirred at 100 °C in an oil bath. The reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature and quenched by water. The resultant product was filtered/extracted with EtOAc to get the product. Crude products were either recrystallized from ethanol or purified by column chromatography using silica as the stationary phase and EtOAc: pet. ether as mobile phase. The products obtained were known compounds and were identified by melting point and ¹H and ¹³C NMR spectroscopy. The spectral data were compared with the literature values.

References:

Indalkar, Krishna S;Khatri, Chetan K;Chaturbhuj, Ganesh U [Journal of Chemical Sciences,2017,vol. 129,# 2,p. 141 - 148]

21745-41-5 Synthesis

21745-41-5
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$42.00/1g

517-21-5 Synthesis