2-Chloroquinoxaline synthesis
- Product Name:2-Chloroquinoxaline
- CAS Number:1448-87-9
- Molecular formula:C8H5ClN2
- Molecular Weight:164.59
1196-57-2
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1448-87-9
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Yield:1448-87-9 93%
Reaction Conditions:
with trichlorophosphate in toluene; for 1 h;Reflux;
Steps:
0 Step 0: Preparation of Precursor Quinaxoline
The chlorination of the 2-hydroxy quinoxaline was carried out in neat POCl3 (2.3 eqs) at reflux for an hour and produced the 2-chloro-quinoxaline (1D-008) in very good yield. This chemistry was tested on 100 g scale and afforded typically 103-105 g (98-99%). A quick filtration through a Pad of silica of the crude reaction mixture resulted in clean material (99% pure by LCMS). This reaction has beenscaled up to 600 g.
References:
US2017/143706,2017,A1 Location in patent:Paragraph 0050; 0106; 0107
1196-57-2
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$6.00/10g
1448-87-9
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$10.00/500mg
6935-29-1
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1448-87-9
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5227-59-8
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1448-87-9
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95-54-5
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1448-87-9
161 suppliers
$10.00/500mg