5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE synthesis
- Product Name:5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE
- CAS Number:70978-54-0
- Molecular formula:C8H6BrNO4
- Molecular Weight:260.04
1450-75-5
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70978-54-0
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Yield: 73%
Reaction Conditions:
with nitric acid in tetrachloromethane
Steps:
1 1I 5-Bromo-2-hydroxy-3-nitroacetophenone
1I 5-Bromo-2-hydroxy-3-nitroacetophenone A solution of 5-bromo-2-hydroxyacetophenone (23.7 g, 0.110 mol) in carbon tetrachloride (90 ml) was added with concentrated nitric acid (17.2 ml). The mixture was left under stirring at 75° C. for 50 minutes, then left to cool at room temperature. The precipitated solid was recovered by filtration washing with cold carbon tetrachloride. After drying under vacuum, 20.9 g of the title product were obtained as a light yellow solid (73% yield). 1 H N.M.R. (300 MHz, CDCl3) δ ppm: 2.73 (s, 3H); 8.14 (d, 1H); 8.31 (d, 1H); 12.92 (s, 1H).
References:
Laboratorios Menarini S.A. US5990142, 1999, A