5-(4'-BENZYLOXYPHENYL)-2-OXAZOLIDONE synthesis
- Product Name:5-(4'-BENZYLOXYPHENYL)-2-OXAZOLIDONE
- CAS Number:88693-98-5
- Molecular formula:C16H15NO3
- Molecular Weight:269.3
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Yield:-
Reaction Conditions:
in tetrahydrofuran; for 4 h;Reflux;
Steps:
3.2 STEP 2 (1427) (1428) 5-(4-(Benzyloxy)phenyl)oxazolidin-2-one
STEP 2 (1427) (1428) 5-(4-(Benzyloxy)phenyl)oxazolidin-2-one: (1429) To a solution of 2-amino-1-(4-(benzyloxy)phenyl)ethan-1-ol in dry tetrahydrofuran (THF) (0.2M) is added 1,10-carbonyldiimidazole (CDI) (3 eq.) at room temperature. The reaction is refluxed for approximately 4 hours and then the solvent is removed under reduced pressure. The resultant residue is diluted with water (20 mL) and ethyl acetate (20 mL) and the layers are separated. The organic layer is washed with 2 N hydrochloric acid (15 mL), water (10 mL) and dried over anhydrous sodium sulfate. The mixture is reduced and purified by silica gel column chromatography using hexane: ethyl acetate as eluent to afford 5-(4- (benzyloxy)phenyl)oxazolidin-2-one.
References:
WO2017/197051,2017,A1 Location in patent:Page/Page column 363
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