4''-PROPYL-3-FLUOROBIPHENYL-4-BORONIC ACID synthesis

7synthesis methods

Product Name:4''-PROPYL-3-FLUOROBIPHENYL-4-BORONIC ACID
CAS Number:909709-42-8
Molecular formula:C15H16BFO2
Molecular Weight:258.1

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4''-PROPYL-3-FLUOROBIPHENYL-4-BORONIC ACID

909709-42-8
130 suppliers
$18.60/250mg

Yield:909709-42-8 65%

Reaction Conditions:

Stage #1: 3-fluoro-1-(4-propylphenyl)benzenewith n-butyllithium in tetrahydrofuran at -80;Inert atmosphere;
Stage #2: Trimethyl borate in tetrahydrofuran;Inert atmosphere;
Stage #3: waterwith hydrogenchloride in tetrahydrofuran at 0;Inert atmosphere;

Steps:

1.e; 6.e; 7.e

e) Dissolve 214g (1mol) of the product obtained in step d) in 2L of tetrahydrofuran, and replace the air with nitrogen.Cool down to -80, add 443ml (1.1mol) n-butyllithium dropwise,Obtain the lithium reagent. After the addition, add 125g (1.2mol) trimethyl borate in 500ml tetrahydrofuran solution to replace lithium. After the natural temperature rises to 0°C,Pour into 2L of water, add 200ml of concentrated hydrochloric acid, separate, extract, wash with water, and evaporate to dryness to obtain 168g product with a yield of 65%.

References:

CN107312549,2021,B Location in patent:Paragraph 0088-0092; 0098; 0148; 0151-0153; 0158; 0160; ...

121-43-7
358 suppliers
$14.00/25mL

948044-01-7
18 suppliers
inquiry

909709-42-8
130 suppliers
$18.60/250mg

References