ChemicalBook CAS DataBase List 4-(Piperazino)indole

4-(Piperazino)indole synthesis

4synthesis methods

Product Name:4-(Piperazino)indole
CAS Number:84807-09-0
Molecular formula:C12H15N3
Molecular Weight:201.27

5192-23-4 Synthesis

5192-23-4
289 suppliers
$10.00/250mg

821-48-7 Synthesis

821-48-7
554 suppliers
$6.00/25g

84807-09-0
81 suppliers
$97.00/250mg

Yield:84807-09-0 90.8%

Reaction Conditions:

with potassium carbonate in isopropyl alcohol at 90; for 48 h;

Steps:

1.1 Step 1) Synthesis of 4-(piperazin-1-yl)-1H-indole

4-aminoindole (2g, 15.2mmol), bis(2-chloroethyl)amine hydrochloride (3.2g, 18.2mmol) and potassium carbonate (4.2g, 30.4mmol) was added to isopropanol (30 mL) after the reaction solution was reacted at 90 °C for 48 hours, and thereto was added dichloromethane (50mL) and methanol (50mL). The reaction mixture was filtered and the filtrate under reduced pressure to spin dry, the residue was purified by silica gel column chromatography (dichloromethane/methanol (v/v)= 10/1) by to give the title compound as a brown solid (2.78g, 90.8%).

References:

CN105367472,2016,A Location in patent:Paragraph 0179; 0180; 0181; 0182