ChemicalBook CAS DataBase List 4-isopropylbenzaldehyde semicarbazone

4-isopropylbenzaldehyde semicarbazone synthesis

5synthesis methods

Product Name:4-isopropylbenzaldehyde semicarbazone
CAS Number:950-07-2
Molecular formula:C11H15N3O
Molecular Weight:205.26

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Yield:-

Reaction Conditions:

with sodium acetate in ethanol;water;

Steps:

Synthesis of 5-substituted-1,3,4-oxadiazol-2-amines (4a-j)

General procedure: To an aqueous solution of semicarbazidehydrochloride (1:1g) and sodium acetate (8:2g),substituted benzaldehydes (1a-j) (0.02 mol) in 15 mlof ethanol were added by stirring, stirring wascontinued for another 15-30 min then the mixture waskept aside undisturbed for 1 hr and the obtainedprecipitate was collected and purified byrecrystallization from ethanol.The prepared semicarbazones (3a-j) (0.005 mol)were heated with stirring at 80-85 0 with water andsodium hypoiodate (NaOI) solution for 4-5 hr, thereaction mixture was cooled and the precipitate wascollected and recrystallized from ethanol.

References:

Joshi, Shrinivas D.;Dixit, Sheshagiri R.;More, Uttam A.;Kulkarni, Venkatrao H. [Indian Journal of Heterocyclic Chemistry,2014,vol. 24,# 2,p. 137 - 140]

51433-48-8 Synthesis