4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:26892-90-0
- Molecular formula:C12H11NO3
- Molecular Weight:217.22
Yield: 76%
Reaction Conditions:
in ethanol at 100 - 200; for 3 h;
Steps:
Ethyl 4-hydroxyquinoline-3-carboxylate
Aniline (1.02 mL, 0.011 mol) and diethyl ethoxymethylenemalonate (0.5-2 eq) were weighed into ethanol and heated at 100-200 ° C for three hours.Cool to room temperature, add phenyl ether, heat at 100-200 ° C for 30 min, cool to room temperature,After the reaction was completed, ice water was added, and ethyl acetate (100 mL × 2) was added, and the organic phase was combined, and the organic phase was washed with saturated brine.Dry over anhydrous sodium sulfate, filter,The organic phase was concentrated and the residue was purified by silica gel column chromatography1.6 g (76% yield);
References:
Ocean University of China;Shao Changlun;Li Debao;Jiao Yahan CN108623581, 2018, A Location in patent:Page/Page column 6
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