ChemicalBook CAS DataBase List ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE

ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE synthesis

4synthesis methods

Product Name:ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE
CAS Number:77156-78-6
Molecular formula:C13H13NO4
Molecular Weight:247.25

104-94-9 Synthesis

104-94-9
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$9.00/1g

87-13-8
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$5.00/5g

ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE

77156-78-6
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$40.00/1g

Yield:77156-78-6 78%

Reaction Conditions:

with diphenyl ether-biphenyl eutectic in ethanol; for 0.5 h;Heating / reflux;

Steps:

4.a

A solution of 4-methoxyaniline (4Og, 0.32 mole) and diethyl ethoxymethylenemalonate (65 mL, 0.32 mole) in Dowtherm A (500 mL) was heated at reflux in a flask fitted with side-arm and condenser, and heating was continued until all the ethanol had distilled off (ca. 0.5 hr). The solution was cooled and pentane was added to give a sticky precipitate. The solvents were decanted off and the residue was treated with more pentane and allowed to stand overnight. The solid was filtered off and washed well with pentane to give the title compound (62.4 g; 78%, contains traces of Dowtherm A).

References:

WO2006/81289,2006,A2 Location in patent:Page/Page column 19

83507-70-4 Synthesis