4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE synthesis
- Product Name:4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE
- CAS Number:1701-18-4
- Molecular formula:C10H6F3NO
- Molecular Weight:213.16
Yield:1701-18-4 51.82%
Reaction Conditions:
with toluene-4-sulfonic acid in toluene at 140;Dean-Stark;
Steps:
4.1 Step 1: Synthesis2-(Trifluoromethyl)quinolin-4-ol (4-2)
Ethyl 4,4,4-trifluoro-3-oxobutanoate (8.000mL, 54.315mmol),Aniline (9.909mL, 108.631mmol),Toluene (100.0mL) and p-toluenesulfonic acid (0.47g, 2.716mmol) were addedIn the round-bottomed flask of the Dean-Stark trap connected to the reflux condenser,The mixture was heated to 140°C and refluxed overnight.After the reaction, the mixture was cooled to room temperature,Then use saturated NH4HCO3 aqueous solution (200mL),Wash with water (3×200mL) and saturated brine (200mL),The organic phase was dried with anhydrous sodium sulfate and concentrated,Obtain a residue.Silica gel column chromatography of the residue(Petroleum ether: ethyl acetate = 80:20)After purification, the target product is obtained as a white solid(6.0 g, 28.145 mmol, 51.82% yield).
References:
CN113234079,2021,A Location in patent:Paragraph 0219; 0221; 0222; 0223; 0224
1701-24-2
130 suppliers
$17.00/1g
629-30-1
255 suppliers
$8.00/1g
372-31-6
473 suppliers
$5.00/10g
![2,4-Undecadienamide, 3-methyl-N-(2-methylpropyl)-11-[[2-(trifluoromethyl)-4-quinolinyl]oxy]-, (E,E)- (9CI)](/CAS/20210305/GIF/124467-00-1.gif)
124467-00-1
0 suppliers
inquiry
1701-18-4
105 suppliers
$9.00/1g