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ChemicalBook CAS DataBase List 4-CHLORO-BENZIMIDIC ACID ETHYL ESTER
40546-41-6

4-CHLORO-BENZIMIDIC ACID ETHYL ESTER synthesis

5synthesis methods
-

Yield:40546-41-6 36.8 g (90%)

Reaction Conditions:

with hydrogenchloride in ethanol;

Steps:

R.13.1 Synthesis of [5-benzyloxycarbonylamino-2-(4-chlorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]acetic acid.

(1) Ethyl 4-chlorobenzimidate hydrochloride was synthesised in the same manner as in Reference Example 2. That is, p-chlorobenzonitrile (25.6 g, 0.186 mol) was reacted with hydrogen chloride in ethanol (250 mL) to give 36.8 g (90%) of the target compound as colorless crystals.

References:

US5948785,1999,A

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