4-Chloro-3-nitrobenzenesulfonyl chloride synthesis
- Product Name:4-Chloro-3-nitrobenzenesulfonyl chloride
- CAS Number:97-08-5
- Molecular formula:C6H3Cl2NO4S
- Molecular Weight:256.06
98-60-2
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$5.00/5g
97-08-5
228 suppliers
$10.00/1g
Yield:97-08-5 71%
Reaction Conditions:
with sulfuric acid;nitric acid at 30 - 60;
Steps:
2
1L three bottles were added 500mL concentrated H2SO4, p-chlorobenzenesulfonyl chloride 190g (0.9mol, 1eq) and heated to 30 ° C, dropping fuming nitric acid 56. 7g (0. 9mo 1,1 eq) to keep the temperature below 60 ° C, After the addition the internal temperature was stirred overnight at 55 ° C, TLC (PE / EA = 10/1). The reaction was cooled, poured into ice water, extracted with DCM, dried, filtered and concentrated to give 3-nitro-4-chlorobenzenesulfonyl chloride, white crystals 163g, yield 71%
References:
Shaoyuan Science And Technology (Shanghai) Co., Ltd.;Mei Kai;Lu Yabing;Wu Yong CN106699614, 2017, A Location in patent:Paragraph 0020
6671-49-4
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97-08-5
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$10.00/1g
88-73-3
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$16.00/25g
97-08-5
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17691-19-9
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$45.00/1mg
97-08-5
228 suppliers
$10.00/1g
635-22-3
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$17.67/1gm:
97-08-5
228 suppliers
$10.00/1g