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ChemicalBook CAS DataBase List 4-Bromo-3-nitrobenzotrifluoride
349-03-1

4-Bromo-3-nitrobenzotrifluoride synthesis

3synthesis methods
-

Yield:349-03-1 38%

Reaction Conditions:

with copper(I) bromide;lithium bromide in tetrahydrofuran at 160; for 6 h;Product distribution / selectivity;

Steps:

11
The above reaction was repeated but using acetic acid, acetonitrile or tetrahydrofuran instead of benzonitrile at various concentrations (0.02, 0.04, 0.1 and 1 ml/mmol). Table 14 shows the results, from which it may be seen that the optimal concentration depends upon the solvent, and that the best results were obtained at high concentration.

References:

Bayer CropScience S.A. US6635780, 2003, B1 Location in patent:Page/Page column 12

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