2-Bromo-5-(trifluoromethyl)aniline synthesis
- Product Name:2-Bromo-5-(trifluoromethyl)aniline
- CAS Number:454-79-5
- Molecular formula:C7H5BrF3N
- Molecular Weight:240.02
Yield:393-36-2 33% ，454-79-5 28%
Reaction Conditions:
with tetrabutylammomium bromide;copper(ll) bromide in ethanol at 45;regioselective reaction;
Steps:
General procedure for the synthesis of 1b-14ba, 15b-44b
General procedure: A round bottom flask was charged with Bu4NBr (2 mmol, 0.64 g), EtOH (8 mL) and 2-methylaniline (2 mmol, 0.21 g) followed by CuBr2 (3 mmol, 0.67 g). The resulted mixture was stirred at 25 °C. After the completion of the reaction (monitored by TLC), the solvent was evaporated under reduced pressure. To the residue was added ammonium hydroxide (5 mL, 25% w/v) and water (5 mL) with stirring, and the suspension was extracted with DCM(10 mL×4) The organic phase was washed with saturated brine and dried over anhydrous Na2SO4. The product 2b was obtained using flash chromatograph column eluted with PE : EA (5 : 1).
References:
Zhao, Hong-Yi;Yang, Xue-Yan;Lei, Hao;Xin, Minhang;Zhang, San-Qi [Synthetic Communications,2019,vol. 49,# 11,p. 1406 - 1415] Location in patent:supporting information
349-03-1
208 suppliers
$8.00/5g
454-79-5
237 suppliers
$21.50/1g
98-16-8
382 suppliers
$9.00/5g
454-79-5
237 suppliers
$21.50/1g
98-16-8
382 suppliers
$9.00/5g
454-79-5
237 suppliers
$21.50/1g
58458-10-9
82 suppliers
$21.00/1g
393-36-2
308 suppliers
$6.00/1g