ChemicalBook CAS DataBase List 4-Bromo-3-nitroanisole

4-Bromo-3-nitroanisole synthesis

7synthesis methods

Product Name:4-Bromo-3-nitroanisole
CAS Number:5344-78-5
Molecular formula:C7H6BrNO3
Molecular Weight:232.03

33844-21-2 Synthesis

33844-21-2
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$15.00/1 g

5344-78-5
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$6.00/5g

Yield:5344-78-5 67%

Reaction Conditions:

with 2.9-dimethyl-1,10-phenanthroline;oxygen;copper (I) acetate;silver sulfate;sodium bromide in dimethyl sulfoxide at 160; for 24 h;Schlenk technique;

Steps:

26 Example 26. Synthesis of 2-nitro-4-methoxy bromobenzene.
Silak reaction tube equipped with a magnetic stirrer was charged with 6.2 mg of silver sulfate,36.3 mg of copper acetate, 12.5 mg of 2,9-dimethyl-1,10-o-phenanthroline,39.4 mg of 2-nitro-4-methoxybenzoic acid and 30.9 mg of sodium bromide4 mL of dimethyl sulfoxide. Heat 160 ° C in the presence of oxygenReaction for 24 hours. After the reaction was completed, distilled water was added to quench the reaction,Extraction with ethyl acetate 3 times, each time 10mL,The combined organic phases are concentrated,31.1 mg of 2-nitro-4-methoxybromobenzene was obtained in a yield of 67%.

References:

Nanchang University;Fu Zhengjiang;Cai Hu;Li Zhaojie;Jiang Ligao CN107325002, 2017, A Location in patent:Paragraph 0118

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