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ChemicalBook CAS DataBase List 4-METHOXY-3-NITROANILINE
577-72-0

4-METHOXY-3-NITROANILINE synthesis

9synthesis methods
-

Yield:577-72-0 98.1%

Reaction Conditions:

with PdCu/graphene double-metal catalyst at 60; under 7500.75 Torr; for 0.583333 h;Pressure;Time;Reagent/catalyst;

Steps:

7

The prepared 2,4-dinitroanisole (II) was dissolved in 2 kg of methanol solution, followed by the addition of 60 g of Example 1PdCu / graphene bimetallic catalyst prepared by catalytic hydrogenation reduction reaction,Reaction pressure is 1Mpa,Reaction temperature is 60 ,Reaction time 35min,The reaction is over.After the filter to remove the catalyst,Distillation recovery of methanol,Washed,749.26 g of 4-amino-2-nitroanisole (III) (HPLC purity 99.6%) was obtained,Yield 98.1%.

References:

CN107673976,2018,A Location in patent:Paragraph 0059-0060; 0072; 0081

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