ChemicalBook CAS DataBase List 4-AMINO-N,N-DIMETHYLBENZYLAMINE

4-AMINO-N,N-DIMETHYLBENZYLAMINE synthesis

6synthesis methods

Product Name:4-AMINO-N,N-DIMETHYLBENZYLAMINE
CAS Number:6406-74-2
Molecular formula:C9H14N2
Molecular Weight:150.22

6331-71-1 Synthesis

6331-71-1
87 suppliers
$18.00/100mg

6406-74-2
129 suppliers
$30.00/1g

Yield: 71%

Reaction Conditions:

with aluminum (III) chloride;lithium aluminium tetrahydride in tetrahydrofuran at 5;

Steps:

2.2 Example 2 4-(dimethylaminomethyl)aniline
To a 500 ml three-mouth bottle by adding 200 ml of THF, cooling to 5 °C the following add 17.3g (0.46mol, 4 . 0eq) of lithium aluminum hydride, then lower the temperature to the -5 ° C the following, the three aluminum chloride 3.0g (0.023mol, 0 . 2eq) THF slowly dropwise to the reaction in the solution, stirring for 10 min, temperature at 5 °C the following starting to drop plus step amide 19.0g (0.114mol, 1 . 0eq) in 100 ml of solution THF. Added after stirring overnight TLC inspection reaction end, cooling to 0 °C the following, starting the dropping water filtration, the filter cake is washed with dichloromethane eluviation, concentrated filtrate, vacuum distillation, to obtain colorless oily liquid 12.0g product. Yield: 71.0%, GC: 99.9%

References:

Shao Yuan Science and Technology (Shanghai) Co., Ltd.;Wu, Yong;Lei, Ting jun;Qi, Ming CN105461659, 2016, A Location in patent:Paragraph 0039; 0041; 0040