4-Amino-2-chloropyridine synthesis
- Product Name:4-Amino-2-chloropyridine
- CAS Number:14432-12-3
- Molecular formula:C5H5ClN2
- Molecular Weight:128.56
14432-16-7
213 suppliers
$10.00/1g
14432-12-3
538 suppliers
$5.00/5g
Yield:14432-12-3 85%
Reaction Conditions:
with hydrogenchloride;iron in ethanol;water;Reflux;
Steps:
1.3
(3) 2-chloro-4-nitropyridine N-oxide (7.9g, 0.05mol) in 500ml three-neck flask, iron powder (14g, 0.25mol), ethanol 150ml, water 50ml, 5ml of concentrated hydrochloric acid was heated to reflux , TLC to monitor the completion of the reaction, ethyl acetate was added until the reaction was complete 30ml, stirring was allowed to stand suction, delamination, dried over anhydrous sodium sulfate, and concentrated to give the product 2-chloro-4-aminopyridine, molar yield 85%
References:
CN109748865,2019,A Location in patent:Paragraph 0016; 0019; 0022
23056-36-2
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14432-12-3
538 suppliers
$5.00/5g
73583-37-6
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$9.00/1g
14432-12-3
538 suppliers
$5.00/5g
14432-16-7
213 suppliers
$10.00/1g
142-96-1
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$14.00/25mL
14432-12-3
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$5.00/5g
109-09-1
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14432-12-3
538 suppliers
$5.00/5g