ChemicalBook CAS DataBase List 4,6-DIPHENYL-2-PYRONE

4,6-DIPHENYL-2-PYRONE synthesis

9synthesis methods

Product Name:4,6-DIPHENYL-2-PYRONE
CAS Number:17372-52-0
Molecular formula:C17H12O2
Molecular Weight:248.28

14371-10-9 Synthesis

14371-10-9
315 suppliers
$6.00/25g

16883-69-5
82 suppliers
$8.00/1g

17372-52-0
36 suppliers
$40.79/1g

Yield: 85%

Reaction Conditions:

with 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate;3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone;potassium carbonate in tetrahydrofuran at 30; for 12 h;Schlenk technique;Sealed tube;

Steps:

1 Preparation of 4,6-diphenyl-2H-pyran-2-one (3a)
General procedure: Weigh 0.11mmol Substituted phenyl ethanone-2-pyridinium bromide salt 2, 0.02mmol nitrogen heterocyclic carbene catalyst 0.12mmol potassium carbonate (K2CO3) as a base. Add to a 10mL Schlenk reaction tube equipped with a magnetic stir bar, add 1.5mL of solvent tetrahydrofuran (THF), then add 0.10mmol substituted phenyl cinnamaldehyde 1, gently shake the reaction wall to mix it well. Close the bottle cap and place in an oil bath at 30 ° C to fully stir the reaction for 12h. After the reaction was monitored by TLC, spin dry, load, and separate by column chromatography. The eluent was polar petroleum ether: ethyl acetate = 10: 1 to obtain the target compound. After weighing, the corresponding yield was calculated. The compound was passed through the melting point analyzer. And nuclear magnetic resonance NMR.

References:

Guizhou University;Zheng Pengcheng;Wu Shuquan;Liu Changyi;Xue Wei;Chi Yonggui CN110922374, 2020, A Location in patent:Paragraph 0029-0035

14371-10-9 Synthesis

14371-10-9
315 suppliers
$6.00/25g