ChemicalBook CAS DataBase List 4-(5-FORMYL-2-FURYL)BENZOIC ACID

4-(5-FORMYL-2-FURYL)BENZOIC ACID synthesis

7synthesis methods

Product Name:4-(5-FORMYL-2-FURYL)BENZOIC ACID
CAS Number:39245-15-3
Molecular formula:C12H8O4
Molecular Weight:216.19

4-(5-FORMYL-FURAN-2-YL)-BENZOIC ACID METHYL ESTER

53355-29-6
45 suppliers
$45.00/100mg

39245-15-3
51 suppliers
$45.00/50mg

Yield:39245-15-3 96%

Reaction Conditions:

with methanol;water;lithium hydroxideReflux;Inert atmosphere;

Steps:

4.1.3 General procedure for the synthesis of compounds 8a-d

General procedure: LiOH (10mmol) was added to a solution of compounds 7a-e (1mmol) in CH₃OH (10mL) and H₂O (5mL). The reaction mixture was refluxed till ester disappeared in TLC (～1h), acidified with HCl 2N till pH 4-5 and extracted with AcOEt (3×25mL). The combined organic layers were washed with a NaHCO₃ saturated solution (2×20mL) and brine (2×20mL). The desired products 8a-e were obtained as brown-red solid after evaporation of the solvent.

References:

Gentili, Valentina;Turrin, Giulia;Marchetti, Paolo;Rizzo, Sabrina;Schiuma, Giovanna;Beltrami, Silvia;Cristofori, Virginia;Illuminati, Davide;Compagnin, Greta;Trapella, Claudio;Rizzo, Roberta;Bortolotti, Daria;Fantinati, Anna [Bioorganic Chemistry,2022,vol. 119,art. no. 105518]