4,4'-DI-TERT-BUTYLBIPHENYL synthesis
- Product Name:4,4'-DI-TERT-BUTYLBIPHENYL
- CAS Number:1625-91-8
- Molecular formula:C20H26
- Molecular Weight:266.42
Yield:1625-91-8 100%
Reaction Conditions:
iron(III) chloride in dichloromethane at 20;
Steps:
23
To a stirred solution of biphenyl (15.4 g, 100 mmol) and anhydrous ferric chloride (80 mg) in dichlorometfaaiie (100ml) at room temperature was added slowly tert-butyl chloride (23.2 .ml, 21(5 mmol). The reaction was stirred overnight. The product was washed with water and extracted with hexane (100 ml) 3 times. The combined organic phase was washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo and gave 26.6 g of Compound S (yield 100%). 1H NMR (400 MHz, chloroform-d): δ, ppm 7.542 (d, 4 H), 7.444 (d, 4 H), 1.365 (s, 18 H).
References:
WO2006/93466,2006,A1 Location in patent:Page/Page column 37; Sheet 13
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