4-(1H-Imidazol-1-yl)benzaldehyde synthesis

10synthesis methods

Product Name:4-(1H-Imidazol-1-yl)benzaldehyde
CAS Number:10040-98-9
Molecular formula:C10H8N2O
Molecular Weight:172.18

288-32-4 Synthesis

288-32-4
1014 suppliers
$5.00/25g

15164-44-0
295 suppliers
$6.00/1g

10040-98-9
171 suppliers
$6.00/1g

Yield:10040-98-9 94%

Reaction Conditions:

with potassium carbonate in dimethyl sulfoxide at 120; for 12 h;Inert atmosphere;

Steps:

General procedure for the copper-catalyzedN-arylation of nitrogen-containing heterocycles with aryl halides

General procedure: To a mixture of 0.05 g catalyst and aryl halide (1.0 mmol)in 9.0 cm3 DMSO, Het-NH (1.2 mmol) and K2CO3(2.0 mmol) was added and the mixture was vigorouslystirred at 120 C for the appropriate time under a drynitrogen atmosphere. After completion (as monitored byTLC), the catalyst was filtered, and the filtrate wasextracted with ethyl acetate (3 9 20 cm3) and the combinedorganic layers were dried with anhydrous MgSO4,filtered, and evaporated under reduced pressure. The residuewas purified by column chromatography. The purity ofthe compounds was checked by 1H NMR and yields arebased on aryl bromide. All the products are known and thespectroscopic data (FT-IR and NMR) and melting pointswere consistent with those reported in the literature [36-41].

References:

Nasrollahzadeh, Mahmoud;Zahraei, Ali;Pourbasheer, Eslam [Monatshefte fur Chemie,2015,vol. 146,# 8,p. 1329 - 1334]

288-32-4 Synthesis

288-32-4
1014 suppliers
$5.00/25g

459-57-4 Synthesis