ChemicalBook CAS DataBase List 3-Pyridinemethanol

3-Pyridinemethanol synthesis

14synthesis methods

Product Name:3-Pyridinemethanol
CAS Number:100-55-0
Molecular formula:C6H7NO
Molecular Weight:109.13

614-18-6
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$5.00/10g

100-55-0
397 suppliers
$8.00/5g

Yield:100-55-0 90%

Reaction Conditions:

with C₃₀H₃₄Cl₂N₂P₂Ru;potassium methanolate;hydrogen in tetrahydrofuran at 100; under 38002.6 - 76005.1 Torr; for 10 h;Glovebox;Autoclave;

Steps:

27 Example 27: Hydrogenation of ester compounds catalyzed by ruthenium complex Ia

General procedure: In a glove box, add a ruthenium complex Ia (0.3 to 0.7 mg, 0.0002 to 0.001 mmol) to a 300 mL autoclave,Potassium methoxide (35-700 mg, 0.5-10 mmol), tetrahydrofuran (4-60 mL), and ester compounds (10-200 mmol).After sealing the autoclave, take it out of the glove box and fill it with 50 100atm of hydrogen.The reaction kettle was heated and stirred in an oil bath at 100 ° C for 10 to 336 hours.After the reaction kettle was cooled in an ice-water bath for 1.5 hours, the excess hydrogen was slowly released.The solvent was removed from the reaction solution under reduced pressure, and the residue was purified with a short silica gel column to obtain an alcohol compound. The results are shown in Table 5.

References:

CN110357923,2019,A Location in patent:Paragraph 0301-0303; 0306

93-60-7 Synthesis