ChemicalBook CAS DataBase List 3-PHENOXYPHENETHYLAMINE

3-PHENOXYPHENETHYLAMINE synthesis

10synthesis methods

Product Name:3-PHENOXYPHENETHYLAMINE
CAS Number:51061-22-4
Molecular formula:C15H17NO
Molecular Weight:227.3

29973-97-5 Synthesis

2-[3-(benzyloxy)phenyl]ethan-1-amine hydrochloride

29973-97-5
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51061-22-4
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Yield:-

Reaction Conditions:

with sodium hydroxide in dichloromethane;water;

Steps:

2.A

To a stirred solution of 3-benzyloxyphenylacetonitrile (24.88 g, 111 mol) in THF (100 mL), a borane-THF (1.0 M, 167 mL, 167 mmol) in THF solution was added. The resulting solution was refluxed overnight. Methanol was then added to destroy excess borane, and the reaction mixture was concentrated. Hydrochloric acid (6 N, 30 mL) was added. The resulting white precipitate from the solution was collected by filtration and dried to yield a solid, as its corresponding HCl salt. The HCl salt was converted to the free base by dissolution in dichloromethane and subsequently washed with sodium hydroxide solution (1.0 N) to yield a colorless oil. MH⁺=228.2

References:

US2007/232630,2007,A1 Location in patent:Page/Page column 18

20967-96-8 Synthesis