天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 3-Fluoropyridine-4-carboxylic acid
393-53-3

3-Fluoropyridine-4-carboxylic acid synthesis

11synthesis methods
-

Yield:393-53-3 70%

Reaction Conditions:

Stage #1:3-Fluoropyridine with n-butyllithium;diisopropylamine in tetrahydrofuran at -78; for 1 h;
Stage #2:carbon dioxide in tetrahydrofuran at -78 - 20; for 1 h;
Stage #3: with hydrogenchloride in tetrahydrofuran;water; pH=5

Steps:

1
3-Fluoropyridine (25 g, 257mmol) was added to a solution of butyllithium EPO (270 mmol) and diisopropylamine (27.4 g, 271 mmol) in tetrahydrofuran (600 mL) at - 78°C. After stirring for one hour, crushed dry ice was added to the solution and the solution was warmed to room temperature during one hour. Aqueous hydrogen chloride was added to the solution to acidify the solution to pH 5. The resulting precipitate was filtered and dried. The title compound (25.2 g, 179 mmol, 70%) was obtained as colorless crystal.

References:

MITSUBISHI PHARMA CORPORATION;SANOFI-AVENTIS WO2006/36015, 2006, A2 Location in patent:Page/Page column 121-122

FullText

3-Fluoropyridine-4-carboxylic acid Related Search: