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ChemicalBook CAS DataBase List 5-AMINO-2-FLUORO-ISONICOTINIC ACID
171178-43-1

5-AMINO-2-FLUORO-ISONICOTINIC ACID synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 91 percent / various solvent(s) / 10 h / 40 - 45 °C
2.1: n-BuLi; TMEDA / hexane; various solvent(s) / 3 h / -15 - -10 °C
2.2: 64 percent / hexane; various solvent(s) / 2 h / -70 °C
3.1: 85 percent / trifluoroacetic acid / CH2Cl2 / 3 h / 20 °C

References:

Zhang, Yinsheng;Huang, Yun;Huang, Che C. [Journal of labelled compounds and radiopharmaceuticals,2005,vol. 48,# 7,p. 485 - 496]

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