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ChemicalBook CAS DataBase List 3-CHLORO-5-FLUOROBENZYL ALCOHOL
79944-64-2

3-CHLORO-5-FLUOROBENZYL ALCOHOL synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1: 62 percent / (NH4)2S / methanol / 5 h / Heating
2: 1.) HNO2, 2.) CuCl2, CuCl, 12percent aq. HCl / 1.) 0 deg C, 2.) 60 deg C, 1 h
3: 81 percent / Fe, HCl (gas) / ethanol
4: 65 percent / aq. HBF4, NaNO2 / -5 °C
5: 25 percent / Heating

References:

Meindl;Von Angerer;Schonenberger;Ruckdeschel [Journal of Medicinal Chemistry,1984,vol. 27,# 9,p. 1111 - 1118]

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