ChemicalBook CAS DataBase List 3-CHLORO-2-FLUOROPHENOL

3-CHLORO-2-FLUOROPHENOL synthesis

4synthesis methods

Product Name:3-CHLORO-2-FLUOROPHENOL
CAS Number:2613-22-1
Molecular formula:C6H4ClFO
Molecular Weight:146.55

261762-56-5 Synthesis

261762-56-5
101 suppliers
$9.00/1g

2613-22-1
131 suppliers
$6.00/1g

Yield:2613-22-1 60%

Reaction Conditions:

with hydrogen bromide at 100 - 110; for 7 h;

Steps:

1.4; 2-15
(4) Put 112.4g of 2-fluoro-3-chloroanisole obtained in step (3) and 600g of 50% hydrobromic acid into a 2L four-necked flask, heat it up to 100-110°C, reflux and keep incubating for 7 hours, and sample and control it. HPLC: 2-fluoro-3-chloroanisole≤5%, 2-fluoro-3-chlorophenol≥95%, stop the reaction. Cool down to 20-30°C, add 300g of dichloromethane*3 and extract three times, then strip the oil layer with 200g of 20% liquid caustic soda, cool the water layer to 0-10°C, slowly add hydrochloric acid dropwise to adjust pH=1-2, a large amount of precipitation White crystals are filtered, washed with a small amount of water, and dried under vacuum at 20-30°C for 24 hours to obtain 87.9 g of 2-fluoro-3-chlorophenol. HPLC: ≥98%, total yield 60%

References:

Zhejiang Yongtai Technology Co., Ltd.;Shao Hongming;Zhang Xing;Yu Bo;Hu Jie;Li Hongkui CN112142567, 2020, A Location in patent:Paragraph 0041; 0046-0047; 0049-0050; 0052-0053; 0055-0056

FullText

2106-04-9 Synthesis