3-ALLYL-7-CHLORO-2-MERCAPTO-3H-QUINAZOLIN-4-ONE synthesis
1synthesis methods
- Product Name:3-ALLYL-7-CHLORO-2-MERCAPTO-3H-QUINAZOLIN-4-ONE
- CAS Number:91063-29-5
- Molecular formula:C11H9ClN2OS
- Molecular Weight:252.72
Yield:91063-29-5 47%
Reaction Conditions:
at 80; for 1 h;Green chemistry;
Steps:
3.3. Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones by Mixing and HeatingPreparation of DESs
General procedure: Anthranilic acid 1-5 (1 mmol) and corresponding isothiocyanate (1.2 mmol) wereadded to 10 mL of DES and stirred at 80 C for 1 h. Upon completion of the reaction, waterwas added, and the precipitated product was filtered off. When necessary, a recrystallizationwas performed using ethanol.
References:
Jerkovi?, Igor;Komar, Mario;Kraljevi?, Tatjana Gazivoda;Molnar, Maja [Molecules,2022,vol. 27,# 2,art. no. 558]