3,5-Difluorochlorobenzene synthesis
- Product Name:3,5-Difluorochlorobenzene
- CAS Number:1435-43-4
- Molecular formula:C6H3ClF2
- Molecular Weight:148.54
108-70-3
249 suppliers
$19.89/442235
372-38-3
314 suppliers
$9.00/1g
1435-43-4
230 suppliers
$7.00/5g
Yield:372-38-3 74% ，1435-43-4 6.7%
Reaction Conditions:
with potassium fluoride;3-nitro-N,N-dimethylbenzamide;1,3-dimethyl-2-(N',N',N",N"-tetramethylguanidino)-4,5-dihydro-3H-imidazolium chloride in sulfolane at 220; under 6000.6 Torr; for 48 h;
Steps:
4
Example 4; Preparation method of 1,3,5-trifluorobenzene; 500 g of 1,3,5-trichlorobenzene, 1180 ml of sulpholane, 10.7 g of 3-nitrodimethylbenzamide and 640 g of dry KF were initially charged in an autoclave, then 48 g of CNC catalyst were added and the autoclave was sealed. The mixture was heated to 220° C. for 48 h. During the reaction, a maximum total pressure of 8 bar arose. Subsequently, the mixture was cooled to 20° C. The product was distilled off initially at standard pressure, later under reduced pressure. 310 g of a colourless liquid having a proportion of 87% by weight of 1,3,5-trifluorobenzene (74% of theory) and 8.8% by weight of difluorochlorobenzene (6.7% by weight of theory) were obtained. 1,3,5-Trifluorobenzene and difluorochlorobenzene can be separated distillatively in a known manner.
References:
Pleschke, Axel;Marhold, Albrecht US2006/9643, 2006, A1 Location in patent:Page/Page column 5
108-70-3
249 suppliers
$19.89/442235
1435-43-4
230 suppliers
$7.00/5g
36556-56-6
159 suppliers
$7.00/1g
1435-43-4
230 suppliers
$7.00/5g
80-73-9
566 suppliers
$8.00/25g
108-70-3
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$19.89/442235
141-93-5
123 suppliers
$44.00/2ml
1435-43-4
230 suppliers
$7.00/5g
2265-94-3
226 suppliers
$10.00/1g
1435-43-4
230 suppliers
$7.00/5g