3,4-Dimethoxyhydrocinnamic acid synthesis
- Product Name:3,4-Dimethoxyhydrocinnamic acid
- CAS Number:2107-70-2
- Molecular formula:C11H14O4
- Molecular Weight:210.23
Yield:2107-70-2 2.5 g (47.6%)
Reaction Conditions:
with formic acid;triethylamine in water;benzene
Steps:
19 Preparation of 3-(3,4-dimethoxyphenyl)propionic acid
EXAMPLE 19 Preparation of 3-(3,4-dimethoxyphenyl)propionic acid After weighing in 6.25 ml of the mixture of formic acid and triethylamine (prepared as described in Example 1) to 25 ml of benzene, 4.15 g (0.025 mol) of veratraldehyde and 3.6 g (0.025 mol) of Meldrum's acid were added and the reaction mixture was refluxed for 4 hours. After evaporating the benzene under reduced pressure, 50 ml of water were added to the evaporation residue, the pH value was adjusted to 1 with concentrated hydrochloric acid, then the method of Example 1 was followed. A yield of 2.5 g (47.6%) was achieved, m.p.: 95°-97° C.
References:
Biogal Gyogyszergrar US5350872, 1994, A
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