ChemicalBook CAS DataBase List 3-[2-(diethylamino)ethoxy]aniline

3-[2-(diethylamino)ethoxy]aniline synthesis

3synthesis methods

Product Name:3-[2-(diethylamino)ethoxy]aniline
CAS Number:34334-19-5
Molecular formula:C12H20N2O
Molecular Weight:208.3

213606-47-4 Synthesis

213606-47-4
5 suppliers
inquiry

34334-19-5
8 suppliers
inquiry

Yield:34334-19-5 80%

Reaction Conditions:

with tin(ll) chloride in ethanol; for 2 h;Heating / reflux;

Steps:

2.2g

3-(2-Diethylamino-ethoxy)-phenylamine can be prepared by the following procedure. To a solution of diethyl-[2-(3-nitro-phenoxy)-ethyl]-amine (2.72 mmol) (from Example Ig) in EtOH (20 mL) is added SnCl₂-2H₂O (10.9 mmol). The suspension is refluxed for 2 h. After this time the solvent is removed under reduced pressure. The residue is dissolved in 5% NaOH (50 mL) and extracted withEtOAc (3 x 50 mL). The organic layer is washed once with 5% NaOH (20 mL), brine, dried over Na₂SO₄ and concentrated to afford the aniline as a brown oil (80%). MS (m/z) (M+l)⁺ 209.1.

References:

WO2007/38669,2007,A2 Location in patent:Page/Page column 175