(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid synthesis
- Product Name:(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- CAS Number:28416-82-2
- Molecular formula:C21H26F2O5
- Molecular Weight:396.42
2135-17-3
399 suppliers
$31.00/50mg
28416-82-2
223 suppliers
$60.00/50mg
Yield:28416-82-2 100%
Reaction Conditions:
with water;periodic acid in tetrahydrofuran at 20; for 1 h;
Steps:
To a suspension of flumethasone (1.19 g, 2.9 mmol) in tetrahydrofuran (11 ml) was added a solution of periodic acid (2.25 g, 9.9 mmol) in water (5.3 ml). The resulting solution was stirred at RT for 1 h. The tetrahydrofuran was removed in vacuo to leave an aqueous suspension which was filtered, and the solid washed with water and dried to give 1.17 g (100%) of the title compound as a colourless solid.
References:
US2010/99654,2010,A1 Location in patent:Page/Page column 5