ChemicalBook CAS DataBase List 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride synthesis

5synthesis methods

Product Name:1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
CAS Number:25952-53-8
Molecular formula:C8H18ClN3
Molecular Weight:191.7

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride can be used for the synthesis of amides. It is used as a coupling agent in the synthesis of esters from carboxylic acids using dimethylaminopyridine as the catalyst.

1892-57-5 Synthesis

1892-57-5
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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

25952-53-8
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$9.00/25g

Yield:25952-53-8 92%

Reaction Conditions:

with triethylamine hydrochloride in acetonitrile at 15; for 1 h;Temperature;

Steps:

Add 1100 g of triethylamine hydrochloride to a 3000 ml reaction flask.1000g of acetonitrile, wherein the mass ratio of triethylamine to HCL is 5:1,EDC213.6g was slowly added dropwise, and the temperature was controlled at 15 °C.The dropping time is controlled at 60 min, filtered,EDC hydrochloride was obtained with a purity of 99.5% and a yield of 92%.

References:

CN109369458,2019,A Location in patent:Paragraph 0025; 0034; 0035; 0039; 0040; 0044

628-13-7 Synthesis