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ChemicalBook CAS DataBase List (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid
254452-86-3

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: DMSO; P2O5; Et3N
2.1: NaOH; (n-octyl)3MeNCl / toluene; H2O
3.1: DIBAH
4.1: NaH; n-BuLi
5.1: NaBH4; Et2BOMe / -78 °C
6.1: aq. NaOH
6.2: (-)-α-methylbenzylamine

References:

Suzuki, Mikio;Yanagawa, Yoshinobu;Iwasaki, Hiroshi;Kanda, Hiroyasu;Yanagihara, Kazufumi;Matsumoto, Hiroo;Ohara, Yoshio;Yazaki, Yukari;Sakoda, Ryozo [Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,# 20,p. 2977 - 2982]

256431-72-8 Synthesis
(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile

256431-72-8
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(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid

254452-86-3
14 suppliers
inquiry

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