2-PHENOXYPROPIOPHENONE synthesis

9synthesis methods

Product Name:2-PHENOXYPROPIOPHENONE
CAS Number:6640-19-3
Molecular formula:C15H14O2
Molecular Weight:226.27

2114-00-3
7 suppliers
$15.00/5g

108-95-2 Synthesis

108-95-2
739 suppliers
$14.00/25g

6640-19-3
5 suppliers
$90.00/500mg

Yield:6640-19-3 85%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20; for 24 h;Inert atmosphere;Williamson Ether Synthesis;

Steps:

Synthesis of α-oxyketones 1d-p, 1s-w and 6

General procedure: General experimental procedure B (GEP-B): To a clean and oven-dried flask 1 equiv of the corresponding α-bromo ketone SM2-6 or desyl chloride (SM1), anhydrous DMF, 1.1-1.3 equiv of K₂CO₃ and 1.1-1.3 equiv of the corresponding phenol were added under nitrogen atmosphere. The mixture was allowed to react for 24 h at r.t. The reaction was worked up with H₂O (15 mL) and extracted with Et₂O (3 × 15 mL). The organic layers were combined, washed with aqueous NaOH (2 × 20 ml, 10% w/w) and dried over anhydrous Na₂SO₄. After evaporation under reduced pressure, the crude residue was purified by flash column chromatography on silica gel (eluent: hexane/EtOAc) to obtain α-oxy ketones 1 and 6.

References:

Sedano, Carlos;Virumbrales, Cintia;Suárez-Pantiga, Samuel;Sanz, Roberto [Synthesis,2021,vol. 53,# 20,p. 3725 - 3734] Location in patent:supporting information

721-04-0 Synthesis