ChemicalBook CAS DataBase List 2-Pentanol

2-Pentanol synthesis

11synthesis methods

Product Name:2-Pentanol
CAS Number:6032-29-7
Molecular formula:C5H12O
Molecular Weight:88.15

By catalytic reduction of methyl n-propyl ketone.

107-87-9
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6032-29-7
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$14.00/5mL

Yield:6032-29-7 99%

Reaction Conditions:

with sodium isopropylate;acetonitrile in isopropyl alcohol at 80; for 1 h;Catalytic behavior;

Steps:

2.2.4 General Procedure forHydrogenation ofKetonesUsing Feimine-mont-K10 astheCatalyst
General procedure: The hydrogenation of ketones was carried out by taking15mg of Feimine-mont-K10 catalyst (19.9mol%),1mmol of ketone, 5mL sodium iso-propoxide (Na-i-OPr),5mL acetonitrile and i-PrOH (5mL) in a round bottomedflask and stirring at 80°C for required time (Table5). Theprogress of the reaction was monitored from time to timeby thin layer chromatography (TLC) using 5% ethylacetate-hexane as the eluent. After completion of the reaction(monitored by GC-MS), the catalyst was separatedby filtration. The filtrate was diluted with water (10mL)and then extracted with ethyl acetate (10mL) followedby washing with brine and dehydrated using anhydrousNa2SO4.The resulting residue was purified by silica gelcolumn chromatography using ethylacetate-hexane (5:95)as the eluent to get the pure products. In order to recyclethe catalyst, it was separated from the reaction mixture bycentrifugation and then washed several times with waterand ethyl acetate after each cycle. After drying at 110°Cin an oven for overnight, the recovered catalyst was subjectedto subsequent runs under same reaction conditions.

References:

Sultana, Samim;Borah, Geetika;Gogoi, Pradip. K. [Catalysis Letters,2019,vol. 149,# 8,p. 2142 - 2157]

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