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ChemicalBook CAS DataBase List 2-methyl-3-furaldehyde
5612-67-9

2-methyl-3-furaldehyde synthesis

11synthesis methods
-

Yield:5612-67-9 72%

Reaction Conditions:

with tetrapropylammonium perruthennate;4-methylmorpholine N-oxide in dichloromethane at 20; for 1 h;4A sieves;

Steps:

29

To a solution 2-methyl-furan-3-methanol (0.47g, 4.18mmol), N-methyl morpholine N-oxide (0.58g, 5. 02mmol), and crushed, dried, and activated 4A sieves (2. 0g) in anhydrous dichloromethane (15ml) is added tetrapropyl ammonium peruthenate (0.14g, 0. 42minol). The reaction mixture is stirred for one hour at room temperature, then filtered through a silica gel plug and eluted with ethyl acetate. The filtrate is concentrated ira vacuo to give 2-methyl-furan-3-carboxaldehyde (0.33g, 72%) which is used without further purification. lH NMR (CDC13) : 6 = 9.88 (1H, s), 7.25 (1H, s), 6.63 (1H, s), 2.55 (3H, s).

References:

WO2005/92885,2005,A1 Location in patent:Page/Page column 77

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