2,5-DIMETHYL-3-FUROIC ACID synthesis
- Product Name:2,5-DIMETHYL-3-FUROIC ACID
- CAS Number:636-44-2
- Molecular formula:C7H8O3
- Molecular Weight:140.14
29113-63-1
25 suppliers
$156.00/50mg
636-44-2
94 suppliers
$13.00/500mg
Yield:636-44-2 92%
Reaction Conditions:
with sodium hydroxide in methanol at 60; for 2 h;
Steps:
7.3 5-(tertButyl)-2-methylfuran-3-carboxylic acid (3a) and 2,5-dimethylfuran-3-carboxylic acid (3b)
A stirred solution of ethyl 5-tertbutyl-2-methylfuran-3-carboxylate 2a (2.16g, 10.27mmol) or ethyl 2,5-dimethylfuran-3-carboxylate 2b (1.73g, 10.27mmol) in anhydrous methanol (30mL) was added with 2M sodium hydroxide solution (10.27mL, 20.55mmol) at 60°C for 2h, after the anhydrous methanol was removed under reduced pressure, adjusted to pH 1. A lot of precipitated white solid was filtered and dried in vacuo at 40°C for 24h to give a light white solid. 3a (1.57g, yield: 83.9%), mp: 88.2-91.5°C; MS (ESI) m/z (%): 180.8 [M-H]-; 3b (1.32g, yield: 92.0%); mp: 136.0-138.4°C; MS (ESI) m/z (%): 138.8 [M-H]-. 1H NMR (DMSO-d6, 300 MH): δ 2.18 (s, 3H), 2.43 (s, 3H), 6.18 (s, 1H), 12.34 (s, 1H).
References:
Zhao, Dongmei;Sun, Bin;Ren, Jinhong;Li, Fengrong;Song, Shuai;Lv, Xuejiao;Hao, Chenzhou;Cheng, Maosheng [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 6,p. 1356 - 1365]
10599-70-9
181 suppliers
$9.00/1g
636-44-2
94 suppliers
$13.00/500mg
127-17-3
528 suppliers
$5.00/10g
636-44-2
94 suppliers
$13.00/500mg
625-86-5
197 suppliers
$20.00/25mL
636-44-2
94 suppliers
$13.00/500mg
41892-81-3
37 suppliers
$65.00/50mg
636-44-2
94 suppliers
$13.00/500mg