2-Methyl-2-adamantanol synthesis
- Product Name:2-Methyl-2-adamantanol
- CAS Number:702-98-7
- Molecular formula:C11H18O
- Molecular Weight:166.26
Yield:702-98-7 99%
Reaction Conditions:
Stage #1: 2-Adamantanone;methylmagnesium chloride in tetrahydrofuran at 0; for 0.5 h;
Stage #2: with ammonium chloride in tetrahydrofuran;
Steps:
3M Methylmagnesium chloride in THF (44 mL), was added through a canula to adamantan-2-one(10 g, 66.66 mmol) in THF (50 mL) at 0 °C. After stirring at 0 °C for 0.5 h, the reaction mixture was quenched by adding saturated NH4C1 solution. The organic layer was separated and the aqueous layer was extracted with EtOAc. The combined organic layer was washed with water and brine, dried over Na2S04 and the solvent was removed under reduced pressure to afford 2-methyladamantan-2-ol (11 g, 99% yield) as an off-white solid.
References:
WO2011/58582,2011,A1 Location in patent:Page/Page column 27
![Tricyclo[4.4.0.03,8]decan-2-ol, 2-methyl- (8CI)](/CAS/20210305/GIF/20497-75-0.gif)
20497-75-0
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