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ChemicalBook CAS DataBase List 2-Ethylhexyl bromide
18908-66-2

2-Ethylhexyl bromide synthesis

4synthesis methods
-

Yield:18908-66-2 96.6%

Reaction Conditions:

with phosphorus tribromide at 20 - 65;Large scale;

Steps:

1.1.1; 1.1.2; 1.1.3; 1.1.4 First, the bromination reaction:

1, to the bromination kettle was added 500kg (content of 99.5%) of isooctanol, 0.5kg of catalyst,368 kg (content 98.0%) of phosphorus tribromide was added dropwise at 20-30 ° C,About 4 hourscatalyst2, after dropping,Slowly warmed to 60-65 incubated 3-4 hours, GC analysis,Isooctanol content ≤ 0.5% reaction is complete;3, points to the bottom of the reactor phosphorous acid, bottling,The upper oil is crude bromo isooctane,Into the washing kettle, washed to neutral;4, the lower bromo isooctane crude separation,With 10kg (content 98.0%) concentrated sulfuric acid stirred for a short time washing, the lower part of the waste acid,Top to add water to neutral,Layers were 730kgBromo isooctaneIntermediate (content 98.5%, water 0.8%), yield 96.6%;

References:

CN106565569,2017,A Location in patent:Paragraph 0047; 0048; 0049; 0050; 0051

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