2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE synthesis
- Product Name:2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
- CAS Number:723286-98-4
- Molecular formula:C4H2ClF3N2O
- Molecular Weight:186.52
762240-99-3
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$33.79/250mg
723286-98-4
130 suppliers
$33.00/1g
Yield: 90.2%
Reaction Conditions:
with trichlorophosphate in 1,2-dichloro-ethane at 80 - 85;Reagent/catalyst;Temperature;
Steps:
1-2 Example 1
In a 500ml reaction flask, add 200g of 1,2-dichloroethane and 40.8g of 1-(chloroacetyl)-2-(trifluoroacetyl)hydrazine, add 61.32g of phosphorus oxychloride under stirring at room temperature, and heat up to Incubate at 80-85 and react for 20-24 hours, lower the temperature to below 10, add 200g of water dropwise, separate the organic layer, add 100g of 5% sodium bicarbonate aqueous solution, stir and wash until neutral, separate the organic layer, concentrate and recover 1, With 2-dichloroethane, 33.64 g of oily product was obtained, with a yield of 90.2% and a purity of 97.3%.
References:
CN112480021, 2021, A Location in patent:Paragraph 0012-0017
1538-08-5
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$5.00/100mg
79-04-9
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$12.00/5g
723286-98-4
130 suppliers
$33.00/1g